HIV envelope gp120-mediated regulation of osteoclastogenesis via receptor activator of nuclear factor kappa B ligand (RANKL) secretion and its modulation by certain HIV protease inhibitors through interferon-gamma/RANKL cross-talk. [electronic resource]
- The Journal of biological chemistry Nov 2003
- 48251-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M304676200 doi
Animals Bone Diseases, Metabolic--metabolism Bone Resorption CD3 Complex--biosynthesis Carrier Proteins--metabolism Cell Line Cells, Cultured Cysteine Endopeptidases--metabolism Cytokines--metabolism Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay HIV Envelope Protein gp120--metabolism HIV Protease Inhibitors--pharmacology Humans Immunoblotting Indinavir--pharmacology Interferon-gamma--metabolism Membrane Glycoproteins--metabolism Mice Multienzyme Complexes--metabolism Nelfinavir--pharmacology Osteoclasts--metabolism Precipitin Tests Protease Inhibitors--pharmacology Proteasome Endopeptidase Complex Protein Binding RANK Ligand Receptor Activator of Nuclear Factor-kappa B Ritonavir--pharmacology