Lleó, Alberto <br/><br/>
Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.  [electronic resource] 

 -  The Journal of biological chemistry  Nov 2003 
 - 47370-5 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M308480200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amyloid Precursor Protein Secretases<br/>Amyloid beta-Protein Precursor--metabolism<br/>Animals<br/>Aspartic Acid Endopeptidases<br/>Binding, Competitive<br/>Blotting, Western<br/>Cell Line<br/>Cell Line, Tumor<br/>Down-Regulation<br/>Endopeptidases--metabolism<br/>Enzyme-Linked Immunosorbent Assay<br/>Feedback, Physiological<br/>Humans<br/>Luciferases--metabolism<br/>Membrane Proteins--biosynthesis<br/>Mice<br/>Plasmids--metabolism<br/>Presenilin-1<br/>Protein Binding<br/>Protein Structure, Tertiary<br/>Receptor, Notch1<br/>Receptors, Cell Surface--genetics<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>Signal Transduction<br/>Transcription Factors<br/>Transfection<br/>beta-Galactosidase--metabolism