TY  - GEN
AU  - Watanabe,Nobuhide
AU  - Ikeno,Akihisa
AU  - Minato,Hisao
AU  - Nakagawa,Hiroshi
AU  - Kohayakawa,Chie
AU  - Tsuji,Jun-ichi
TI  - Discovery and preclinical characterization of (+)-3-[4-(1- piperidinoethoxy)phenyl]spiro[indene- 1,1'-indane]-5,5'-diol hydrochloride: a promising nonsteroidal estrogen receptor agonist for hot flush
SN  - 0022-2623
PY  - 2003///1110
KW  - Animals
KW  - Bone Density
KW  - drug effects
KW  - Breast Neoplasms
KW  - metabolism
KW  - Cholesterol
KW  - blood
KW  - Drug Evaluation, Preclinical
KW  - Estradiol
KW  - analogs & derivatives
KW  - Female
KW  - Hot Flashes
KW  - drug therapy
KW  - Indans
KW  - chemistry
KW  - Male
KW  - Morphine Dependence
KW  - Naloxone
KW  - pharmacology
KW  - Piperidines
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptors, Estrogen
KW  - agonists
KW  - Selective Estrogen Receptor Modulators
KW  - Skin Temperature
KW  - Spiro Compounds
KW  - Stereoisomerism
KW  - Tumor Cells, Cultured
KW  - Uterus
N1  - Publication Type: Comparative Study; Journal Article
UR  - https://doi.org/10.1021/jm034134+
ER  -