Watanabe, Nobuhide <br/><br/>
Discovery and preclinical characterization of (+)-3-[4-(1- piperidinoethoxy)phenyl]spiro[indene- 1,1'-indane]-5,5'-diol hydrochloride: a promising nonsteroidal estrogen receptor agonist for hot flush.  [electronic resource] 

 -  Journal of medicinal chemistry  Sep 2003 
 - 3961-4 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm034134+  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Bone Density--drug effects<br/>Breast Neoplasms--metabolism<br/>Cholesterol--blood<br/>Drug Evaluation, Preclinical<br/>Estradiol--analogs & derivatives<br/>Female<br/>Hot Flashes--drug therapy<br/>Indans--chemistry<br/>Male<br/>Morphine Dependence--metabolism<br/>Naloxone--pharmacology<br/>Piperidines--chemistry<br/>Rats<br/>Rats, Sprague-Dawley<br/>Receptors, Estrogen--agonists<br/>Selective Estrogen Receptor Modulators--chemistry<br/>Skin Temperature--drug effects<br/>Spiro Compounds--chemistry<br/>Stereoisomerism<br/>Tumor Cells, Cultured<br/>Uterus--drug effects