Iron tetrakis (N-methyl-4'-pyridyl) porphyrinato inhibits proliferative activity of thymocytes by blocking activation of p38 mitogen-activated protein kinase, nuclear factor-kappaB, and interleukin-2 secretion. [electronic resource]
- Toxicology and applied pharmacology Sep 2003
- 147-55 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0041-008X
10.1016/s0041-008x(02)00044-3 doi
Animals Cell Division--drug effects Cell Line Cell Survival--drug effects Concanavalin A--pharmacology Dose-Response Relationship, Drug Down-Regulation Enzyme Activation--drug effects Ferric Compounds--pharmacology In Vitro Techniques Interleukin-2--metabolism Male Metalloporphyrins--pharmacology Mice Mice, Inbred Strains Mitogen-Activated Protein Kinases--biosynthesis NF-kappa B--biosynthesis Thymus Gland--cytology p38 Mitogen-Activated Protein Kinases