Quinsey, Noelene S <br/><br/>
Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability.  [electronic resource] 

 -  Biochemistry  Sep 2003 
 - 10169-73 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0006-2960 
<br/><br/><label>Standard No.: </label>10.1021/bi0349322  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Substitution<br/>Antithrombins--chemistry<br/>Drug Stability<br/>Heparin--analogs & derivatives<br/>Hot Temperature<br/>Humans<br/>Kinetics<br/>Models, Molecular<br/>Mutagenesis, Site-Directed<br/>Osmolar Concentration<br/>Protein Denaturation<br/>Protein Structure, Secondary<br/>Recombinant Proteins--chemistry<br/>Structure-Activity Relationship<br/>alpha 1-Antitrypsin--chemistry