Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. [electronic resource]
- Circulation Sep 2003
- 1238-45 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
1524-4539
10.1161/01.CIR.0000089082.40285.C3 doi
Acetophenones--therapeutic use Animals Antioxidants--therapeutic use Atrasentan Biopterins--analogs & derivatives Carotid Arteries--drug effects Cyclic N-Oxides--therapeutic use Desoxycorticosterone Disease Models, Animal Endothelin Receptor Antagonists Endothelin-1--pharmacology Endothelium, Vascular--drug effects Enzyme Inhibitors--pharmacology GTP Cyclohydrolase--genetics Gene Transfer Techniques Genetic Therapy--methods Humans Hypertension--chemically induced In Vitro Techniques Male Nitric Oxide--metabolism Pyrrolidines--pharmacology Rats Rats, Sprague-Dawley Receptor, Endothelin A Sodium Chloride Spin Labels Superoxides--metabolism Vasodilation--drug effects