Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway. [electronic resource]
- The Journal of biological chemistry Oct 2003
- 41355-66 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M302830200 doi
Active Transport, Cell Nucleus Blotting, Western Breast Neoplasms--metabolism Cell Cycle Proteins--biosynthesis Cell Division Cell Line, Tumor Cell Nucleus--metabolism Cyclin-Dependent Kinase Inhibitor p27 Cytoplasm--metabolism Down-Regulation Enzyme Activation Estrogens--metabolism Fatty Acids, Unsaturated--pharmacology Flow Cytometry G1 Phase Gene Expression Regulation, Enzymologic Genetic Vectors Humans MAP Kinase Signaling System Mitogen-Activated Protein Kinases--metabolism Models, Biological Mutation Oligonucleotides, Antisense--pharmacology Phosphorylation S-Phase Kinase-Associated Proteins--metabolism Signal Transduction Time Factors Transfection Tumor Suppressor Proteins--biosynthesis