Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult. [electronic resource]
- Journal of neuroscience research Aug 2003
- 537-44 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0360-4012
10.1002/jnr.10671 doi
Animals Anti-Inflammatory Agents, Non-Steroidal--therapeutic use Astrocytes--drug effects Blotting, Western--methods Brain--drug effects Brain Infarction--metabolism Cyclooxygenase 2 Cytokines--genetics Disease Models, Animal Gene Expression Regulation--drug effects Imidazoles--therapeutic use Immunohistochemistry--methods Infarction, Middle Cerebral Artery--physiopathology Isoenzymes--genetics Lectins--metabolism Male Microglia--drug effects Mitogen-Activated Protein Kinase 14 Mitogen-Activated Protein Kinases--antagonists & inhibitors Neurologic Examination Nitric Oxide Synthase--genetics Nitric Oxide Synthase Type II Prostaglandin-Endoperoxide Synthases--genetics Pyridines--therapeutic use RNA, Messenger--biosynthesis Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction--methods Tetrazolium Salts--metabolism Time Factors