TY - GEN AU - McPhie,Donna L AU - Coopersmith,Robert AU - Hines-Peralta,Andrew AU - Chen,Yuzhi AU - Ivins,Kathryn J AU - Manly,Susan P AU - Kozlowski,Michael R AU - Neve,Kim A AU - Neve,Rachael L TI - DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3 SN - 1529-2401 PY - 2003///0903 KW - Alzheimer Disease KW - genetics KW - Amyloid beta-Protein Precursor KW - Animals KW - Apoptosis KW - Bromodeoxyuridine KW - Cell Cycle KW - drug effects KW - Cells, Cultured KW - DNA KW - biosynthesis KW - Genes, Dominant KW - Genetic Vectors KW - In Situ Nick-End Labeling KW - Mutation KW - Nervous System KW - metabolism KW - Neurons KW - cytology KW - Organ Specificity KW - Protein Serine-Threonine Kinases KW - RNA, Messenger KW - Rats KW - Recombinant Fusion Proteins KW - Sequence Deletion KW - Signal Transduction KW - physiology KW - p21-Activated Kinases KW - rab GTP-Binding Proteins KW - rab5 GTP-Binding Proteins N1 - Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S ER -