Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase enhances chemotherapeutic effects on H460 human non-small cell lung cancer cells through activation of apoptosis. [electronic resource]
- Molecular cancer therapeutics Jul 2003
- 641-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1535-7163
Antineoplastic Agents--therapeutic use Apoptosis--drug effects Butadienes--pharmacology Carcinoma, Non-Small-Cell Lung--metabolism Caspases--metabolism Doxorubicin--therapeutic use Drug Synergism Drug Therapy, Combination Enzyme Activation Enzyme Inhibitors--pharmacology Humans JNK Mitogen-Activated Protein Kinases Lung Neoplasms--metabolism MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase 1--antagonists & inhibitors Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors Mitogen-Activated Protein Kinases--antagonists & inhibitors Nitriles--pharmacology Paclitaxel--therapeutic use Phosphorylation Poly(ADP-ribose) Polymerases--metabolism Protein Kinase C--antagonists & inhibitors Proteins--antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2--metabolism Signal Transduction Staurosporine--pharmacology Tumor Cells, Cultured--drug effects X-Linked Inhibitor of Apoptosis Protein bcl-X Protein