Cao, Pei-rang

The DNA minor groove-alkylating cyclopropylpyrroloindole drugs adozelesin and bizelesin induce different DNA damage response pathways in human colon carcinoma HCT116 cells. [electronic resource] - Molecular cancer therapeutics Jul 2003 - 651-9 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

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Antineoplastic Agents, Alkylating--pharmacology
Apoptosis--drug effects
Benzofurans
Cell Cycle--drug effects
Cellular Senescence--drug effects
Colonic Neoplasms--metabolism
Cyclin-Dependent Kinase Inhibitor p21
Cyclins--metabolism
Cyclohexanecarboxylic Acids--pharmacology
Cyclohexenes
DNA Damage
DNA, Neoplasm--drug effects
Dose-Response Relationship, Drug
Duocarmycins
Humans
Indoles--pharmacology
Signal Transduction--drug effects
Tumor Cells, Cultured--drug effects
Tumor Suppressor Protein p53--metabolism
Urea--analogs & derivatives