Woo, Ju-Hyung <br/><br/>
Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.  [electronic resource] 

 -  Carcinogenesis  Jul 2003 
 - 1199-208 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0143-3334 
<br/><br/><label>Standard No.: </label>10.1093/carcin/bgg082  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Blotting, Western<br/>Carcinoma, Renal Cell--metabolism<br/>Caspases--metabolism<br/>Curcumin--pharmacology<br/>Cytochrome c Group--metabolism<br/>Down-Regulation<br/>Enzyme Activation--drug effects<br/>Enzyme Inhibitors--pharmacology<br/>Free Radical Scavengers--pharmacology<br/>Gene Expression Regulation, Neoplastic<br/>Humans<br/>Inhibitor of Apoptosis Proteins<br/>Kidney Neoplasms--metabolism<br/>Mitochondria--drug effects<br/>Poly(ADP-ribose) Polymerases--metabolism<br/>Protein Serine-Threonine Kinases<br/>Proteins--antagonists & inhibitors<br/>Proto-Oncogene Proteins--antagonists & inhibitors<br/>Proto-Oncogene Proteins c-akt<br/>Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors<br/>RNA, Messenger--metabolism<br/>Reactive Oxygen Species<br/>Reverse Transcriptase Polymerase Chain Reaction<br/>Tumor Cells, Cultured<br/>bcl-2-Associated X Protein<br/>bcl-X Protein