TY - GEN AU - Pelletier,Jean-Pierre AU - Fernandes,Julio C AU - Brunet,Julie AU - Moldovan,Florina AU - Schrier,Denis AU - Flory,Craig AU - Martel-Pelletier,Johanne TI - In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes SN - 0004-3591 PY - 2003///0703 KW - Animals KW - Cartilage, Articular KW - drug effects KW - Chondrocytes KW - Collagenases KW - metabolism KW - Disease Models, Animal KW - Enzyme Inhibitors KW - pharmacology KW - Fluorobenzenes KW - Hindlimb KW - surgery KW - Immunohistochemistry KW - Longitudinal Ligaments KW - MAP Kinase Kinase 1 KW - MAP Kinase Kinase 2 KW - Male KW - Matrix Metalloproteinase 1 KW - Mitogen-Activated Protein Kinase 1 KW - Mitogen-Activated Protein Kinase 3 KW - Mitogen-Activated Protein Kinase Kinases KW - antagonists & inhibitors KW - Mitogen-Activated Protein Kinases KW - Osteoarthritis, Knee KW - drug therapy KW - Phosphorylation KW - Protein Serine-Threonine Kinases KW - Protein-Tyrosine Kinases KW - Rabbits KW - Synovial Membrane KW - Synovitis N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1002/art.11014 ER -