Pelletier, Jean-Pierre <br/><br/>
In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes.  [electronic resource] 

 -  Arthritis and rheumatism  Jun 2003 
 - 1582-93 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0004-3591 
<br/><br/><label>Standard No.: </label>10.1002/art.11014  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Cartilage, Articular--drug effects<br/>Chondrocytes--drug effects<br/>Collagenases--metabolism<br/>Disease Models, Animal<br/>Enzyme Inhibitors--pharmacology<br/>Fluorobenzenes--pharmacology<br/>Hindlimb--surgery<br/>Immunohistochemistry<br/>Longitudinal Ligaments--surgery<br/>MAP Kinase Kinase 1<br/>MAP Kinase Kinase 2<br/>Male<br/>Matrix Metalloproteinase 1--metabolism<br/>Mitogen-Activated Protein Kinase 1--metabolism<br/>Mitogen-Activated Protein Kinase 3<br/>Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors<br/>Mitogen-Activated Protein Kinases--metabolism<br/>Osteoarthritis, Knee--drug therapy<br/>Phosphorylation<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Protein-Tyrosine Kinases--antagonists & inhibitors<br/>Rabbits<br/>Synovial Membrane--drug effects<br/>Synovitis--drug therapy