Uchi, Hiroshi <br/><br/>
CX-659S, a diaminouracil derivative, indirectly inhibits the function of Langerhans cells by blocking the MEK1/2-Erk1/2 pathway in keratinocytes.  [electronic resource] 

 -  The Journal of investigative dermatology  Jun 2003 
 - 983-9 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-202X 
<br/><br/><label>Standard No.: </label>10.1046/j.1523-1747.2003.12250.x  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antigens, CD<br/>B7-1 Antigen--metabolism<br/>B7-2 Antigen<br/>Butadienes--pharmacology<br/>Enzyme Inhibitors--pharmacology<br/>Female<br/>Granulocyte-Macrophage Colony-Stimulating Factor--antagonists & inhibitors<br/>Interleukin-2--antagonists & inhibitors<br/>Keratinocytes--drug effects<br/>Langerhans Cells--drug effects<br/>MAP Kinase Kinase 1<br/>MAP Kinase Kinase 2<br/>Membrane Glycoproteins--antagonists & inhibitors<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Inbred C3H<br/>Mitogen-Activated Protein Kinase 1--antagonists & inhibitors<br/>Mitogen-Activated Protein Kinase 3<br/>Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors<br/>Mitogen-Activated Protein Kinases--antagonists & inhibitors<br/>Nitriles--pharmacology<br/>Phosphorylation--drug effects<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Protein-Tyrosine Kinases--antagonists & inhibitors<br/>T-Lymphocytes--metabolism<br/>Uracil--analogs & derivatives