TY  - GEN
AU  - Aranapakam,Venkatesan
AU  - Davis,Jamie M
AU  - Grosu,George T
AU  - Baker,Jannie
AU  - Ellingboe,John
AU  - Zask,Arie
AU  - Levin,Jeremy I
AU  - Sandanayaka,Vincent P
AU  - Du,Mila
AU  - Skotnicki,Jerauld S
AU  - DiJoseph,John F
AU  - Sung,Amy
AU  - Sharr,Michele A
AU  - Killar,Loran M
AU  - Walter,Thomas
AU  - Jin,Guixian
AU  - Cowling,Rebecca
AU  - Tillett,Jeff
AU  - Zhao,Weiguang
AU  - McDevitt,Joseph
AU  - Xu,Zhang Bao
TI  - Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis
SN  - 0022-2623
PY  - 2003///0711
KW  - ADAM Proteins
KW  - ADAM17 Protein
KW  - Administration, Oral
KW  - Animals
KW  - Binding Sites
KW  - Biological Assay
KW  - Cartilage
KW  - drug effects
KW  - Cattle
KW  - Crystallography, X-Ray
KW  - Dialysis
KW  - Dogs
KW  - Haplorhini
KW  - Humans
KW  - Hydroxamic Acids
KW  - chemical synthesis
KW  - Male
KW  - Matrix Metalloproteinase 13
KW  - Matrix Metalloproteinase Inhibitors
KW  - Matrix Metalloproteinases
KW  - chemistry
KW  - Metalloendopeptidases
KW  - antagonists & inhibitors
KW  - Mice
KW  - Models, Molecular
KW  - Osteoarthritis
KW  - drug therapy
KW  - Piperidines
KW  - Protease Inhibitors
KW  - Rabbits
KW  - Rats
KW  - Structure-Activity Relationship
KW  - Sulfones
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm0205550
ER  -