Aranapakam, Venkatesan <br/><br/>
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.  [electronic resource] 

 -  Journal of medicinal chemistry  Jun 2003 
 - 2376-96 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm0205550  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ADAM Proteins<br/>ADAM17 Protein<br/>Administration, Oral<br/>Animals<br/>Binding Sites<br/>Biological Assay<br/>Cartilage--drug effects<br/>Cattle<br/>Crystallography, X-Ray<br/>Dialysis<br/>Dogs<br/>Haplorhini<br/>Humans<br/>Hydroxamic Acids--chemical synthesis<br/>Male<br/>Matrix Metalloproteinase 13<br/>Matrix Metalloproteinase Inhibitors<br/>Matrix Metalloproteinases--chemistry<br/>Metalloendopeptidases--antagonists & inhibitors<br/>Mice<br/>Models, Molecular<br/>Osteoarthritis--drug therapy<br/>Piperidines--chemical synthesis<br/>Protease Inhibitors--chemical synthesis<br/>Rabbits<br/>Rats<br/>Structure-Activity Relationship<br/>Sulfones--chemical synthesis