TY  - GEN
AU  - Aranapakam,Venkatesan
AU  - Grosu,George T
AU  - Davis,Jamie M
AU  - Hu,Baihua
AU  - Ellingboe,John
AU  - Baker,Jannie L
AU  - Skotnicki,Jerauld S
AU  - Zask,Arie
AU  - DiJoseph,John F
AU  - Sung,Amy
AU  - Sharr,Michele A
AU  - Killar,Loran M
AU  - Walter,Thomas
AU  - Jin,Guixian
AU  - Cowling,Rebecca
TI  - Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis
SN  - 0022-2623
PY  - 2003///0711
KW  - ADAM Proteins
KW  - ADAM17 Protein
KW  - Administration, Oral
KW  - Animals
KW  - Biological Assay
KW  - Cartilage
KW  - drug effects
KW  - Cattle
KW  - Dialysis
KW  - Hydroxamic Acids
KW  - chemical synthesis
KW  - Matrix Metalloproteinase 13
KW  - Matrix Metalloproteinase Inhibitors
KW  - Metalloendopeptidases
KW  - antagonists & inhibitors
KW  - Mice
KW  - Osteoarthritis
KW  - drug therapy
KW  - Protease Inhibitors
KW  - Rats
KW  - Structure-Activity Relationship
KW  - Sulfones
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm0205548
ER  -