Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes. [electronic resource]
- Biochemistry Jun 2003
- 6363-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0006-2960
10.1021/bi027391+ doi
Anti-Infective Agents--pharmacology Aryl Hydrocarbon Hydroxylases--chemistry Biochemistry--methods Cells, Cultured Crystallography, X-Ray Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP2C8 Cytochrome P-450 CYP2C9 Cytochrome P-450 Enzyme System--chemistry Cytochrome P450 Family 2 Dose-Response Relationship, Drug Humans Inhibitory Concentration 50 Kinetics Liver--metabolism Microsomes--metabolism Mixed Function Oxygenases--chemistry Models, Chemical Oxygen--metabolism Progesterone--metabolism Protein Binding Protein Folding Protein Structure, Tertiary Steroid 21-Hydroxylase--chemistry Substrate Specificity Sulfaphenazole--chemistry Sulfonamides--chemistry Ultraviolet Rays