TY  - GEN
AU  - Projean,Denis
AU  - Baune,Bruno
AU  - Farinotti,Robert
AU  - Flinois,Jean-Pierre
AU  - Beaune,Philippe
AU  - Taburet,Anne-Marie
AU  - Ducharme,Julie
TI  - In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation
SN  - 0090-9556
PY  - 2004///0112
KW  - Animals
KW  - Aryl Hydrocarbon Hydroxylases
KW  - antagonists & inhibitors
KW  - Biotransformation
KW  - Cells, Cultured
KW  - Chloroquine
KW  - analogs & derivatives
KW  - Chromatography, High Pressure Liquid
KW  - Cytochrome P-450 CYP2C8
KW  - Cytochrome P-450 CYP2D6
KW  - biosynthesis
KW  - Cytochrome P-450 CYP2D6 Inhibitors
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme Inhibitors
KW  - Cytochrome P-450 Enzyme System
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Humans
KW  - Insecta
KW  - Isoenzymes
KW  - Kinetics
KW  - Microsomes, Liver
KW  - drug effects
KW  - Recombinant Proteins
KW  - Spectrometry, Mass, Electrospray Ionization
KW  - Transfection
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/dmd.31.6.748
ER  -