Projean, Denis <br/><br/>
In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Jun 2003 
 - 748-54 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0090-9556 
<br/><br/><label>Standard No.: </label>10.1124/dmd.31.6.748  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors<br/>Biotransformation<br/>Cells, Cultured<br/>Chloroquine--analogs & derivatives<br/>Chromatography, High Pressure Liquid<br/>Cytochrome P-450 CYP2C8<br/>Cytochrome P-450 CYP2D6--biosynthesis<br/>Cytochrome P-450 CYP2D6 Inhibitors<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 Enzyme Inhibitors<br/>Cytochrome P-450 Enzyme System--biosynthesis<br/>Enzyme Inhibitors--pharmacology<br/>Humans<br/>Insecta<br/>Isoenzymes--antagonists & inhibitors<br/>Kinetics<br/>Microsomes, Liver--drug effects<br/>Recombinant Proteins--antagonists & inhibitors<br/>Spectrometry, Mass, Electrospray Ionization<br/>Transfection