Inhibition of interferon (IFN) gamma-induced Jak-STAT1 activation in microglia by vasoactive intestinal peptide: inhibitory effect on CD40, IFN-induced protein-10, and inducible nitric-oxide synthase expression. [electronic resource]
- The Journal of biological chemistry Jul 2003
- 27620-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M303199200 doi
Amino Acid Motifs Animals Binding Sites Blotting, Northern Blotting, Western CD40 Antigens--metabolism Cells, Cultured Central Nervous System--immunology Chemokine CXCL10 Chemokines, CXC--metabolism Cyclic AMP--metabolism Cyclic AMP-Dependent Protein Kinase Type II Cyclic AMP-Dependent Protein Kinases--metabolism DNA-Binding Proteins--metabolism Enzyme Activation Enzyme-Linked Immunosorbent Assay Flow Cytometry Gene Expression Regulation Humans Interferon-gamma--antagonists & inhibitors Janus Kinase 1 Janus Kinase 2 Mice Mice, Inbred BALB C Microglia--metabolism Microscopy, Fluorescence Models, Biological Neuropeptides--metabolism Nitric Oxide Synthase--metabolism Nitric Oxide Synthase Type II Oligonucleotides--chemistry Peptides--chemistry Phosphorylation Pituitary Adenylate Cyclase-Activating Polypeptide Promoter Regions, Genetic Protein Binding Protein-Tyrosine Kinases--metabolism Proto-Oncogene Proteins RNA, Messenger--metabolism STAT1 Transcription Factor Signal Transduction Time Factors Trans-Activators--metabolism Vasoactive Intestinal Peptide--metabolism