Solorzano, Carmen C

Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research May 2003 - 1858-67 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

1078-0432


Animals
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
Apoptosis--drug effects
Cell Division--drug effects
Deoxycytidine--administration & dosage
Dose-Response Relationship, Drug
Endothelium, Vascular--metabolism
Fibroblast Growth Factor 2--metabolism
Humans
Implants, Experimental
Interferon-alpha--administration & dosage
Interleukin-8--metabolism
Male
Matrix Metalloproteinase 9--metabolism
Mice
Mice, Nude
Neoplasm Transplantation
Neoplasms, Experimental
Pancreatic Neoplasms--drug therapy
Platelet Endothelial Cell Adhesion Molecule-1--metabolism
Survival Rate
Tumor Cells, Cultured
Vascular Endothelial Growth Factor A--metabolism
Gemcitabine