Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. [electronic resource]
- The Journal of biological chemistry Jul 2003
- 25386-94 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M302048200 doi
Blotting, Western Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins--pharmacology Cells, Cultured Chondrocytes--metabolism Collagenases--biosynthesis Culture Media, Conditioned--pharmacology DNA--metabolism Dose-Response Relationship, Drug Down-Regulation Fibronectins--chemistry Gene Deletion Humans Insulin-Like Growth Factor I--pharmacology Interleukin-1--chemistry Luciferases--metabolism Matrix Metalloproteinase 13 Models, Genetic Plasmids--metabolism Polymerase Chain Reaction Promoter Regions, Genetic RNA--metabolism RNA, Messenger--metabolism Receptor, IGF Type 1--metabolism Reverse Transcriptase Polymerase Chain Reaction Temperature Transfection Transforming Growth Factor beta Up-Regulation