CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells. [electronic resource]
- The Journal of biological chemistry May 2003
- 18868-76 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M212777200 doi
Binding Sites Biomechanical Phenomena CCAAT-Binding Factor--antagonists & inhibitors Calcium--pharmacology Cells, Cultured Cyclic AMP-Dependent Protein Kinases--metabolism Enzyme Activation Enzyme Inhibitors--pharmacology Gene Expression Regulation Humans Interleukin-1--genetics Ion Channels--physiology MAP Kinase Kinase 1 MAP Kinase Kinase 2 Mitogen-Activated Protein Kinase 1--antagonists & inhibitors Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase Kinases--metabolism Mitogen-Activated Protein Kinases--antagonists & inhibitors Muscle Spindles--physiology Muscle, Smooth--physiology Phosphatidylinositol 3-Kinases--metabolism Physical Stimulation Promoter Regions, Genetic Protein Kinase C--metabolism Protein Serine-Threonine Kinases--metabolism Protein-Tyrosine Kinases--metabolism RNA, Messenger--analysis Respiratory System Reverse Transcriptase Polymerase Chain Reaction Ribosomal Protein S6 Kinases, 90-kDa--metabolism Signal Transduction Transcription Factor AP-1--antagonists & inhibitors p38 Mitogen-Activated Protein Kinases