Chen, Shujuan

The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. [electronic resource] - The Journal of biological chemistry May 2003 - 19526-33 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M300780200 doi


7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide--pharmacology
Animals
Apoptosis--drug effects
Aryl Hydrocarbon Receptor Nuclear Translocator
Carcinogens--pharmacology
Carcinoma, Hepatocellular
Caspases--metabolism
Cytochrome P-450 CYP1A1--genetics
Cytochrome c Group--metabolism
DNA Damage
DNA-Binding Proteins
Dihydroxydihydrobenzopyrenes--pharmacology
Enzyme Activation--drug effects
Fibroblasts
Humans
Liver Neoplasms
Luciferases--genetics
Mice
Mice, Knockout
Mitogen-Activated Protein Kinases--deficiency
Poly(ADP-ribose) Polymerases--metabolism
Proto-Oncogene Proteins c-bcl-2--analysis
Receptors, Aryl Hydrocarbon--physiology
Recombinant Fusion Proteins
Transcription Factors--genetics
Transfection
Tumor Cells, Cultured
bcl-X Protein
p38 Mitogen-Activated Protein Kinases