Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain. [electronic resource]
- Pain Mar 2003
- 135-42 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
0304-3959
10.1016/s0304-3959(02)00346-9 doi
Animals Area Under Curve Disease Models, Animal Dose-Response Relationship, Drug Drug Tolerance Enkephalins--genetics Ganglia, Spinal--metabolism Genetic Vectors Immunohistochemistry--methods Ligation--methods Male Morphine--therapeutic use Naloxone--pharmacology Narcotic Antagonists--pharmacology Oncogene Proteins v-fos--metabolism Pain--drug therapy Pain Measurement Pain Threshold--physiology Protein Precursors Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction--methods Simplexvirus--genetics Spinal Cord Diseases--pathology Time Factors Transgenes