Hao, Shuanglin

Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain. [electronic resource] - Pain Mar 2003 - 135-42 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0304-3959

10.1016/s0304-3959(02)00346-9 doi


Animals
Area Under Curve
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Tolerance
Enkephalins--genetics
Ganglia, Spinal--metabolism
Genetic Vectors
Immunohistochemistry--methods
Ligation--methods
Male
Morphine--therapeutic use
Naloxone--pharmacology
Narcotic Antagonists--pharmacology
Oncogene Proteins v-fos--metabolism
Pain--drug therapy
Pain Measurement
Pain Threshold--physiology
Protein Precursors
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction--methods
Simplexvirus--genetics
Spinal Cord Diseases--pathology
Time Factors
Transgenes