Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. [electronic resource]
- Oncogene Mar 2003
- 1302-16 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0950-9232
10.1038/sj.onc.1206265 doi
Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Adenocarcinoma--metabolism Anthracenes--pharmacology Apoptosis--drug effects Cell Division--drug effects Cell-Free System Culture Media, Serum-Free--pharmacology DNA-Binding Proteins Enzyme Inhibitors--pharmacology Epidermal Growth Factor--antagonists & inhibitors ErbB Receptors--drug effects Flavonoids--pharmacology Humans JNK Mitogen-Activated Protein Kinases MAP Kinase Kinase 1 MAP Kinase Signaling System--drug effects Male Mitogen-Activated Protein Kinase 1--metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors Mitogen-Activated Protein Kinases--antagonists & inhibitors Neoplasm Proteins--antagonists & inhibitors Phosphorylation--drug effects Plant Extracts--pharmacology Prostatic Neoplasms--metabolism Protein Processing, Post-Translational--drug effects Protein Serine-Threonine Kinases--antagonists & inhibitors Proteins--metabolism Proto-Oncogene Proteins--metabolism Seeds--chemistry Shc Signaling Adaptor Proteins Signal Transduction--drug effects Src Homology 2 Domain-Containing, Transforming Protein 1 Transcription Factor AP-1--metabolism Transcription Factors Tumor Cells, Cultured--drug effects Vitis--chemistry ets-Domain Protein Elk-1