Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription. [electronic resource]
- The Journal of biological chemistry May 2003
- 17741-51 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M301602200 doi
8-Bromo Cyclic Adenosine Monophosphate--metabolism Animals Apigenin Blotting, Western Calcimycin--pharmacology Calcium--metabolism Casein Kinase II Cell Line Cloning, Molecular Colforsin--pharmacology Cyclic AMP--metabolism Cyclic AMP Response Element Modulator Cyclic AMP-Dependent Protein Kinase Type II Cyclic AMP-Dependent Protein Kinases--antagonists & inhibitors DNA--metabolism DNA-Binding Proteins--metabolism Electrophoresis, Polyacrylamide Gel Enzyme Activation Enzyme Inhibitors--pharmacology Flavonoids--metabolism Gene Expression Regulation, Enzymologic Genetic Vectors Imidazoles--pharmacology Indoles--pharmacology Interferon-gamma--metabolism Macrophages--enzymology Maleimides--pharmacology Mice Mitogen-Activated Protein Kinases--antagonists & inhibitors Phosphorylation Protein Binding Protein Kinase C--antagonists & inhibitors Protein Serine-Threonine Kinases--metabolism Pyridines--pharmacology RNA, Messenger--metabolism Repressor Proteins Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Sulfonamides--pharmacology Tetradecanoylphorbol Acetate--pharmacology Thapsigargin--pharmacology Time Factors Transcription, Genetic Transcriptional Activation Tyrphostins--pharmacology p38 Mitogen-Activated Protein Kinases