Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Mar 2003
- 2403-8 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0027-8424
10.1073/pnas.0438060100 doi
Animals CHO Cells Cell Line Cricetinae DNA, Complementary--metabolism Dose-Response Relationship, Drug Flow Cytometry Genetic Linkage Glycosylation Humans Integrin alphaVbeta3--chemistry Integrins--chemistry Ligands Models, Molecular Mutation Phenotype Plasmids--metabolism Polysaccharides--chemistry Protein Binding Protein Conformation Protein Structure, Tertiary Transfection