TY - GEN AU - Feling,Robert H AU - Buchanan,Greg O AU - Mincer,Tracy J AU - Kauffman,Christopher A AU - Jensen,Paul R AU - Fenical,William TI - Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora SN - 1433-7851 PY - 2003///0728 KW - Actinomycetales KW - chemistry KW - Adenocarcinoma KW - metabolism KW - Colonic Neoplasms KW - Crystallography, X-Ray KW - Cysteine Endopeptidases KW - Humans KW - Inhibitory Concentration 50 KW - Lactones KW - Magnetic Resonance Spectroscopy KW - Models, Molecular KW - Molecular Structure KW - Multienzyme Complexes KW - antagonists & inhibitors KW - Protease Inhibitors KW - Proteasome Endopeptidase Complex KW - Pyrroles KW - Tumor Cells, Cultured N1 - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1002/anie.200390115 ER -