LaVallee, Theresa M <br/><br/>
2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway.  [electronic resource] 

 -  Cancer research  Jan 2003 
 - 468-75 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0008-5472 
<br/><br/><label>Subjects--Topical Terms: </label><br/>2-Methoxyestradiol<br/>Adaptor Proteins, Signal Transducing<br/>Animals<br/>Apoptosis--drug effects<br/>Apoptosis Regulatory Proteins<br/>Breast Neoplasms--drug therapy<br/>Carrier Proteins--biosynthesis<br/>Caspases--metabolism<br/>Cell Division--drug effects<br/>Drug Synergism<br/>Endothelium, Vascular--cytology<br/>Enzyme Activation<br/>Estradiol--analogs & derivatives<br/>Fas-Associated Death Domain Protein<br/>Female<br/>Humans<br/>Isoenzymes--metabolism<br/>Membrane Glycoproteins--pharmacology<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Nude<br/>Receptors, TNF-Related Apoptosis-Inducing Ligand<br/>Receptors, Tumor Necrosis Factor--antagonists & inhibitors<br/>Signal Transduction--physiology<br/>TNF-Related Apoptosis-Inducing Ligand<br/>Transfection<br/>Tumor Cells, Cultured<br/>Tumor Necrosis Factor-alpha--pharmacology<br/>Up-Regulation--drug effects<br/>Xenograft Model Antitumor Assays