2-[4-(7-chloro-2-quinoxalinyloxyphenoxy]-propionic acid (XK469), an inhibitor of topoisomerase (Topo) IIbeta, up-regulates Topo IIalpha and enhances Topo IIalpha-mediated cytotoxicity. [electronic resource]
- Molecular cancer therapeutics Dec 2002
- 1321-6 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
1535-7163
Antigens, Neoplasm Blotting, Western Culture Media, Serum-Free DNA--metabolism DNA Topoisomerases, Type II--metabolism DNA-Binding Proteins Enzyme Inhibitors--pharmacology Etoposide--pharmacology Humans Immunohistochemistry Leukemia, Lymphocytic, Chronic, B-Cell--blood Microscopy, Confocal Microscopy, Fluorescence Neoplasm Transplantation Protein Isoforms Quinoxalines--pharmacology Time Factors Tumor Cells, Cultured Up-Regulation Waldenstrom Macroglobulinemia--drug therapy