TY  - GEN
AU  - Phornphutkul,Chanika
AU  - Introne,Wendy J
AU  - Perry,Monique B
AU  - Bernardini,Isa
AU  - Murphey,Mark D
AU  - Fitzpatrick,Diana L
AU  - Anderson,Paul D
AU  - Huizing,Marjan
AU  - Anikster,Yair
AU  - Gerber,Lynn H
AU  - Gahl,William A
TI  - Natural history of alkaptonuria
SN  - 1533-4406
PY  - 2003///0102
KW  - 4-Hydroxyphenylpyruvate Dioxygenase
KW  - antagonists & inhibitors
KW  - Adolescent
KW  - Adult
KW  - Age of Onset
KW  - Aged
KW  - Aged, 80 and over
KW  - Alkaptonuria
KW  - classification
KW  - Child
KW  - Child, Preschool
KW  - Connective Tissue Diseases
KW  - etiology
KW  - Cyclohexanones
KW  - therapeutic use
KW  - DNA Mutational Analysis
KW  - Dioxygenases
KW  - Disease Progression
KW  - Enzyme Inhibitors
KW  - Female
KW  - Heart Valve Diseases
KW  - Homogentisate 1,2-Dioxygenase
KW  - Humans
KW  - Joint Diseases
KW  - Kidney Calculi
KW  - Life Tables
KW  - Linear Models
KW  - Longitudinal Studies
KW  - Male
KW  - Middle Aged
KW  - Mutation
KW  - Nitrobenzoates
KW  - Oxygenases
KW  - genetics
KW  - Severity of Illness Index
KW  - Tyrosine
KW  - metabolism
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1056/NEJMoa021736
ER  -