Natural history of alkaptonuria. [electronic resource]
- The New England journal of medicine Dec 2002
- 2111-21 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1533-4406
10.1056/NEJMoa021736 doi
4-Hydroxyphenylpyruvate Dioxygenase--antagonists & inhibitors Adolescent Adult Age of Onset Aged Aged, 80 and over Alkaptonuria--classification Child Child, Preschool Connective Tissue Diseases--etiology Cyclohexanones--therapeutic use DNA Mutational Analysis Dioxygenases Disease Progression Enzyme Inhibitors--therapeutic use Female Heart Valve Diseases--etiology Homogentisate 1,2-Dioxygenase Humans Joint Diseases--etiology Kidney Calculi--etiology Life Tables Linear Models Longitudinal Studies Male Middle Aged Mutation Nitrobenzoates--therapeutic use Oxygenases--genetics Severity of Illness Index Tyrosine--metabolism