Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes. [electronic resource]
- The Journal of biological chemistry Mar 2003
- 9691-7 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M211360200 doi
Animals Cartilage--metabolism Cell Differentiation Cell Division Cells, Cultured Chondrocytes--enzymology Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors--pharmacology Dinoprostone--metabolism Dose-Response Relationship, Drug Enzyme Inhibitors--pharmacology Epidermal Growth Factor--metabolism Gene Expression Regulation, Enzymologic Immunoblotting Immunohistochemistry Indomethacin--pharmacology Isoenzymes--biosynthesis MAP Kinase Signaling System Mitogen-Activated Protein Kinase 1--metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases--metabolism Phenotype Prostaglandin-Endoperoxide Synthases--biosynthesis Rabbits Time Factors p38 Mitogen-Activated Protein Kinases