TY - GEN AU - Tong,Wei-Gang AU - Ding,Xian-Zhong AU - Witt,Richard C AU - Adrian,Thomas E TI - Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway SN - 1535-7163 PY - 2003///0415 KW - Animals KW - Annexin A5 KW - pharmacology KW - Apoptosis KW - Arachidonate 12-Lipoxygenase KW - metabolism KW - Arachidonate 5-Lipoxygenase KW - Arachidonic Acid KW - Blotting, Western KW - Caspase 3 KW - Caspase 7 KW - Caspase 8 KW - Caspase 9 KW - Caspases KW - Cell Division KW - Coloring Agents KW - Cytochrome c Group KW - Cytosol KW - DNA KW - Humans KW - In Situ Nick-End Labeling KW - Lipoxygenase KW - Lipoxygenase Inhibitors KW - Male KW - Mice KW - Mice, Inbred BALB C KW - Mice, Nude KW - Mitochondria KW - Myeloid Cell Leukemia Sequence 1 Protein KW - Neoplasm Proteins KW - Neoplasm Transplantation KW - Pancreatic Neoplasms KW - enzymology KW - Poly(ADP-ribose) Polymerases KW - Proto-Oncogene Proteins c-bcl-2 KW - Quinolines KW - Substrate Specificity KW - Time Factors KW - Tumor Cells, Cultured N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S ER -