Philip, Subha <br/><br/>
Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways.  [electronic resource] 

 -  The Journal of biological chemistry  Apr 2003 
 - 14487-97 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M207309200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Blotting, Western<br/>Cell Line<br/>Cell Movement<br/>Cell Nucleus--metabolism<br/>Cell Survival<br/>Curcumin--pharmacology<br/>Cytoplasm--metabolism<br/>Dose-Response Relationship, Drug<br/>Down-Regulation<br/>Enzyme Activation<br/>Genes, Reporter<br/>I-kappa B Proteins--metabolism<br/>Luciferases--metabolism<br/>Matrix Metalloproteinase 2--metabolism<br/>Mice<br/>Mice, Nude<br/>Microscopy, Fluorescence<br/>Models, Biological<br/>NF-KappaB Inhibitor alpha<br/>NF-kappa B--chemistry<br/>Neoplasm Transplantation<br/>Osteopontin<br/>Phosphorylation<br/>Protein Binding<br/>Protein Precursors--chemistry<br/>Sialoglycoproteins--physiology<br/>Signal Transduction<br/>Transcription Factor RelA<br/>Transcriptional Activation