TY  - GEN
AU  - Brannigan,James A
AU  - Wilkinson,Anthony J
TI  - Protein engineering 20 years on
SN  - 1471-0072
PY  - 2003///0123
KW  - Antibodies
KW  - genetics
KW  - Binding Sites
KW  - Hemoglobins
KW  - Humans
KW  - Insulin
KW  - chemistry
KW  - Molecular Structure
KW  - Mutagenesis, Site-Directed
KW  - Protein Conformation
KW  - Protein Engineering
KW  - Tyrosine-tRNA Ligase
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
UR  - https://doi.org/10.1038/nrm975
ER  -