Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. [electronic resource]
- The Journal of clinical investigation Oct 2002
- 1045-52 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9738
10.1172/JCI15506 doi
3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors Anesthesia Animals Cyclic Nucleotide Phosphodiesterases, Type 4 Male Mice Mice, Inbred C57BL Pentobarbital--pharmacology Phosphodiesterase Inhibitors--adverse effects Receptors, Adrenergic, alpha-2--physiology Time Factors Vomiting--chemically induced