The immunosuppressant rapamycin, alone or with transforming growth factor-beta, enhances osteoclast differentiation of RAW264.7 monocyte-macrophage cells in the presence of RANK-ligand. [electronic resource]
- Calcified tissue international Nov 2002
- 437-46 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0171-967X
10.1007/s00223-001-1138-3 doi
Acid Phosphatase--genetics Animals Carrier Proteins--pharmacology Cell Differentiation--drug effects Cell Division Cell Line Cyclosporine--pharmacology Dose-Response Relationship, Drug Drug Combinations Drug Synergism Immunosuppressive Agents--pharmacology Isoenzymes--genetics Membrane Glycoproteins--pharmacology Mice Monocytes--drug effects Osteoclasts--drug effects RANK Ligand RNA, Messenger--metabolism Receptor Activator of Nuclear Factor-kappa B Receptors, Calcitonin--genetics Sirolimus--pharmacology Tacrolimus--pharmacology Tartrate-Resistant Acid Phosphatase Transforming Growth Factor beta--pharmacology