TY  - GEN
AU  - Yang,Tong
AU  - Espenshade,Peter J
AU  - Wright,Michael E
AU  - Yabe,Daisuke
AU  - Gong,Yi
AU  - Aebersold,Ruedi
AU  - Goldstein,Joseph L
AU  - Brown,Michael S
TI  - Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
SN  - 0092-8674
PY  - 2002///0924
KW  - CCAAT-Enhancer-Binding Proteins
KW  - metabolism
KW  - Cell Membrane
KW  - Cells, Cultured
KW  - Cholesterol
KW  - biosynthesis
KW  - DNA-Binding Proteins
KW  - Endoplasmic Reticulum
KW  - Eukaryotic Cells
KW  - cytology
KW  - Gene Expression Regulation
KW  - physiology
KW  - Genetic Vectors
KW  - Golgi Apparatus
KW  - Homeostasis
KW  - genetics
KW  - Humans
KW  - Intracellular Signaling Peptides and Proteins
KW  - Membrane Proteins
KW  - Mutation
KW  - Peptide Hydrolases
KW  - Protein Binding
KW  - Protein Structure, Tertiary
KW  - Protein Transport
KW  - Proteins
KW  - Sterol Regulatory Element Binding Protein 1
KW  - Sterols
KW  - Transcription Factors
KW  - Transfection
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1016/s0092-8674(02)00872-3
ER  -