Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. [electronic resource]
- Cell Aug 2002
- 489-500 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0092-8674
10.1016/s0092-8674(02)00872-3 doi
CCAAT-Enhancer-Binding Proteins--metabolism Cell Membrane--metabolism Cells, Cultured Cholesterol--biosynthesis DNA-Binding Proteins--metabolism Endoplasmic Reticulum--metabolism Eukaryotic Cells--cytology Gene Expression Regulation--physiology Genetic Vectors--physiology Golgi Apparatus--metabolism Homeostasis--genetics Humans Intracellular Signaling Peptides and Proteins Membrane Proteins--genetics Mutation--genetics Peptide Hydrolases--metabolism Protein Binding--physiology Protein Structure, Tertiary--physiology Protein Transport--physiology Proteins--genetics Sterol Regulatory Element Binding Protein 1 Sterols--metabolism Transcription Factors Transfection