Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. [electronic resource]
- Circulation research Aug 2002
- 300-6 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
1524-4571
10.1161/01.res.0000031799.12850.1e doi
Animals Animals, Newborn Benzoquinones Blotting, Western Chronic Disease Enzyme Activation--drug effects Enzyme Inhibitors--pharmacology Fluorescent Dyes HSP90 Heat-Shock Proteins--antagonists & inhibitors Hypoxia--complications In Vitro Techniques Lactams, Macrocyclic Myocardial Ischemia--complications Nitric Oxide--metabolism Nitric Oxide Synthase--antagonists & inhibitors Nitric Oxide Synthase Type III Oxidative Stress--drug effects Phosphorylation--drug effects Protein Binding Protein Serine-Threonine Kinases Proto-Oncogene Proteins--metabolism Proto-Oncogene Proteins c-akt Quinones--pharmacology Rabbits Recovery of Function--drug effects Serine--metabolism Superoxides--metabolism Ventricular Function, Left--drug effects