Zhang, Fengqin <br/><br/>
(-)U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide] induces internalization and down-regulation of the human, but not the rat, kappa-opioid receptor: structural basis for the differential regulation.  [electronic resource] 

 -  The Journal of pharmacology and experimental therapeutics  Sep 2002 
 - 1184-92 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0022-3565 
<br/><br/><label>Standard No.: </label>10.1124/jpet.302.3.1184  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer--pharmacology<br/>Amino Acid Sequence<br/>Analgesics, Non-Narcotic--pharmacology<br/>Animals<br/>CHO Cells<br/>Cell Membrane--metabolism<br/>Cricetinae<br/>Diprenorphine--metabolism<br/>Down-Regulation--drug effects<br/>Fluorescent Antibody Technique, Direct<br/>Humans<br/>Intracellular Membranes--metabolism<br/>Ionophores--pharmacology<br/>Molecular Sequence Data<br/>Monensin--pharmacology<br/>Mutation--drug effects<br/>Narcotic Antagonists--metabolism<br/>Rats<br/>Receptors, Opioid, kappa--biosynthesis<br/>Recombinant Fusion Proteins--chemistry<br/>Species Specificity