Kuo, Po-Lin The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. [electronic resource] - Life sciences Sep 2002 - 1879-92 p. digital Publication Type: Journal Article ISSN: 0024-3205 Standard No.: 10.1016/s0024-3205(02)01900-8 doi Subjects--Topical Terms: Aloe--chemistryAnimalsAnthraquinonesApoptosis--drug effectsBlotting, WesternCarcinoma, Hepatocellular--pathologyCell Cycle--physiologyCell Division--physiologyEmodin--pharmacologyEnzyme-Linked Immunosorbent AssayGene Expression Regulation, Neoplastic--drug effectsGenes, bcl-2--geneticsGenes, p53--physiologyNucleosomes--chemistryOncogene Protein p21(ras)--physiologyRatsReceptors, Lipoprotein--biosynthesisTumor Cells, Culturedfas Receptor--metabolism