The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway. [electronic resource]
- The Journal of allergy and clinical immunology Aug 2002
- 269-76 p. digital
Publication Type: Journal Article
0091-6749
10.1067/mai.2002.126381 doi
Anti-Inflammatory Agents, Non-Steroidal--pharmacology Antigens, CD--biosynthesis Antigens, CD1--biosynthesis B7-1 Antigen--biosynthesis B7-2 Antigen Biological Transport CD40 Antigens--biosynthesis Calcium-Calmodulin-Dependent Protein Kinases--metabolism Cell Differentiation Cells, Cultured Dendritic Cells--cytology Down-Regulation Endocytosis--drug effects Histocompatibility Antigens Class II--biosynthesis Humans I-kappa B Proteins--metabolism Immunoglobulins--biosynthesis Interleukin-12--metabolism Lipopolysaccharides--pharmacology MAP Kinase Kinase 3 MAP Kinase Kinase 6 MAP Kinase Signaling System Membrane Glycoproteins--biosynthesis Mitogen-Activated Protein Kinase Kinases--metabolism Mitogen-Activated Protein Kinases--metabolism Monocytes--cytology NF-kappa B--antagonists & inhibitors Phosphorylation Protein-Tyrosine Kinases--metabolism Sesquiterpenes--pharmacology Tumor Necrosis Factor-alpha--metabolism Up-Regulation--drug effects p38 Mitogen-Activated Protein Kinases CD83 Antigen