Kelly, Louise M

CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). [electronic resource] - Cancer cell Jun 2002 - 421-32 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1535-6108

10.1016/s1535-6108(02)00070-3 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Bone Marrow Cells--enzymology
Bone Marrow Transplantation
Enzyme Inhibitors--pharmacology
Flow Cytometry
Humans
Immunoblotting
Interleukin-3--metabolism
Leukemia, Myeloid, Acute--drug therapy
Mice
Mice, Inbred BALB C
Mice, Nude
Mutation
Phosphorylation
Piperazines--pharmacology
Proto-Oncogene Proteins--antagonists & inhibitors
Proto-Oncogene Proteins c-kit--drug effects
Quinazolines--pharmacology
Receptor Protein-Tyrosine Kinases--antagonists & inhibitors
Receptors, Cell Surface--antagonists & inhibitors
Receptors, Platelet-Derived Growth Factor--antagonists & inhibitors
Tandem Repeat Sequences
Transfection
Tumor Cells, Cultured--drug effects
fms-Like Tyrosine Kinase 3