TY - GEN AU - Eguchi,Tadashi AU - Sasaki,Satoko AU - Huang,Zhen AU - Kakinuma,Katsumi TI - Importance of specific hydrogen-bond donor-acceptor interactions for the key carbocycle-forming reaction catalyzed by 2-deoxy-scyllo-inosose synthase in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics SN - 0022-3263 PY - 2002///1018 KW - Aminoglycosides KW - Anti-Bacterial Agents KW - biosynthesis KW - Bacillus KW - enzymology KW - Catalysis KW - Chromatography, High Pressure Liquid KW - Cyclization KW - Escherichia coli KW - Glucose-6-Phosphate KW - analogs & derivatives KW - Hexosamines KW - Hydrogen Bonding KW - Hydrogen-Ion Concentration KW - Inositol KW - Kinetics KW - Lyases KW - metabolism KW - Magnetic Resonance Spectroscopy KW - Models, Molecular KW - Molecular Structure KW - Oxidation-Reduction KW - Substrate Specificity N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1021/jo011107n ER -